tdp-43 aggregation

TDP-43 aggregation Kit HTRF

TAR DNA binding protein 43 (TDP-43) is a nucleic acid binding protein involved in RNA-related metabolism. Aggregated TDP-43 has been identified as a

Chemically oligomerizable TDP-43: a novel chemogenetic tool

The substitution of TDP-43 amino acids responsible for RNA binding enhanced aggregate formation, indicating that RNA binding has a negative effect on the phase

TDP-43 proteinopathies: a new wave of neurodegenerative

Cytoplasmic aggregation of hyperphosphorylated TDP-43 (depicted by blue P) is a hallmark of TDP-43 proteinopathies and may result in cellular stress,

Disease-linked TDP-43 hyperphosphorylation suppresses

The major aggregating protein in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), the RNA-binding protein TDP-43,

PDF Aggregates of TDP-43 - NaturePDF

In some neurodegenerative diseases, a protein called TDP-43 forms aggregates in the brain, resulting in neuronal cell death. The structure of these aggregates and their properties have been

USP10 Inhibits Aberrant Cytoplasmic Aggregation of TDP-43

Cytoplasmic TDP-43 aggregates in neurons are a hallmark pathology of ALS. Under various stress conditions, TDP-43 localizes sequentially to two

Cell environment shapes TDP-43 function with implications in

TDP-43 (TAR DNA-binding protein 43) aggregation and redistribution are recognised as a hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. As TDP-43 inclusions have recently been described in the muscle of inclusion body myositis patients, this highlights the need to understand the role of TDP-43 beyond the central nervous system.

Regulation of TDP-43 phosphorylation in aging and disease

Mutations that disrupt TDP-43 RNA binding may contribute to pathogenic mislocalization and aggregation in ALS and FTLD-TDP [31].

The debated toxic role of aggregated TDP-43 in

2019. 5. 1. · Transactive response DNA-binding protein-43 (TDP-43) is an RNA/DNA binding protein that forms phosphorylated and ubiquitinated aggregates in the cytoplasm of motor

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