We review the progressive development of TDP-43 proteinopathy from cytoplasmic mislocalization and misfolding through to macroaggregation and the addition of phosphate and ubiquitin moieties.

Jun 26,  · In this review, we address the function of stress granules, how wild-type and mutant TDP-43 localizes to these structures, affects their formation and disassembly and the possible pathological significance of these findings. 2. Stress granule biology 2.1. Composition and assembly of stress granules

The primary aim of this review is to consolidate the insights that these structures bring to our developing understanding of the functions and deleterious behavior of TDP-43 and to highlight the location of both established and proposed post-translational modifications. Structure Overview

TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in RNA-related metabolism. Hyper-phosphorylated and 

Mar 02,  · Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP or TDP-43) is a key pathological feature of several neurodegenerative diseases, including amyotrophic lateral

Nov 16,  · This review highlights the key physiological functions of the TDP-43 protein, while considering an expanding spectrum of neurodegenerative diseases associated with pathogenic TDP-43 deposition, and dissecting key molecular pathways through which TDP-43 may mediate neurodegeneration. INTRODUCTION

In this review, we focus on evidence of spreading TDP-43 pathology in several neurodegenerative diseases and summarize the published experimental studies supporting cell-to-cell propagation of

Berberine and TDP-43. First time post in this forum - please let me know if I am posting in the wrong section. So my query is a two part questions. I've been coming across a lot of research involving TDP-43 and MND. I was wondering if the research is showing that the misfolded protein is a cause of some/all of the damage occuring in MND or

Jul 30,  · 1. Introduction. Transactive response DNA-binding protein 43 (TDP-43) is a nucleic acid-binding protein that is involved in RNA processing and is essential for the development of the central nervous system [1,2].While many studies have elucidated the pivotal roles of TDP-43 in multiple cellular functions, emerging studies have also uncovered its pathological roles after it

Jan 30,  · transactive response dna-binding protein of 43 kda (tdp-43), an rna and dna binding protein involved in transcriptional repression, rna splicing and rna metabolism during

We review the progressive development of TDP-43 proteinopathy from cytoplasmic mislocalization and misfolding through to macroaggregation and the addition of phosphate and